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KMID : 1024220210360010001
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Environmental Health and Toxicology : EHT
2021 Volume.36 No. 1 p.1 ~ p.1
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Formulation, validation and evaluation studies on metaxalone and diclofenac potassium topical gel
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Tiwari Ashutosh
Bag Puja
Sarkar Mrinmoy
Chawla Viney
Chawla Pooja A.
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Abstract
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Twenty different batches of gels containing metaxalone and diclofenac potassium were prepared for topical application. These drugs act synergistically in the management of pain and inflammation. Gels were prepared by varying the type of gelling agent (ten batches each of hydroxyl propyl methyl cellulose and carbopol 934). The prepared gels were characterized and evaluated. Batch F7 emerged as the best batch on the basis of favourable pH, high drug content, homogeneity and drug release. HPLC (High-performance liquid chromatography) method validation of gel formulation was also carried out and the developed and validated method was found to be robust and accurate.
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KEYWORD
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Carbopol, HPMC, Gels, Diclofenac potassium, Metaxalone, Method validation
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